The European Directorate for the Quality of Medicines and HealthCare (EDQM) is a leading organisation that protects public health by developing and monitoring the application of quality standards for safe medicines and their safe use. These standards are recognised as a scientific benchmark world-wide.
The EDQM offers chemical reference substances (CRS) and biological reference preparations (BRP) as well as reference spectra for the tests and assays to be carried out in accordance with the official methods prescribed in the European Pharmacopoeia. These are characterised at the EDQM laboratory according to the principles described in Chapter 5.12. (Reference Standards) of the European Pharmacopoeia and ‘ISO 17034 General requirements for the competence of reference material producers'.
British Pharmacopoeia chemical reference substances (BPCRS) are primary standards which are establish using absolute methods and the declared content figures are determined without comparing to another substance:
BPCRS is used to perform the tests as per the British Pharmacopeia (BP) or BP (Veterinary). BPCRS are supplied in unit packs containing enough material to carry out the test procedures.
IP Reference Substances, abbreviated to IPRS (and referred to as RS in the individual monographs) are the official standards issued by the Indian Pharmacopoeia Commission (IPC).
Biological Reference Substances are standardized against the International Standards and Reference Preparations established by the World Health Organization (WHO). The potency of these preparations is expressed in International Units.